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KMID : 0978920230240020080
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Korean Journal of Clinical Geriatrics
2023 Volume.24 No. 2 p.80 ~ p.87
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The Effects of Peri-Urethral Thrombin Instillation on Post-Operative Hematuria and Voiding Function in Patients with Benign Prostatic Hyperplasia (BPH) Undergoing Trans-Urethral Prostate Surgery
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Sung Joung-Won
Song Gee-Hyun
Na Woong
Hong Jun-Pyo
Park So-Mi
Seo Seong-Pyo
Yoon Jong-Hyun
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Abstract
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Background: To evaluate the efficacy of peri-urethral thrombin instillation at the surgical site after trans-urethral prostate surgery in benign prostatic hyperplasia (BPH), with the objective of reducing post-operative hematuria and preserving voiding function.
Methods: The study was retrospectively analyzed a total of 122 patients who had trans-urethral prostate surgery between January 2019 and March 2023. Among these, 33 received thrombin instillation, while 89 did not receive it. In the test group, a mixture of 5 cc of saline solution and 5,000 IU of thrombin was instilled below the balloon, targeting the surgical site by inserting a 5 Fr feeding tube along with the Foley catheter. We compared hematologic data and uroflowmetry (UFM) between pre and post-operative periods, the duration of continuous bladder irrigation (CBI) and Foley catheter indwelling period.
Results: The mean age and prostate size in the test group were 71.52±7.15 years and 54.05±24.73 g, while 71.38±8.22 years and 64.52±28.43 g in the control group. The prostate resected weight was 24.97±15.77 g and 27.58±17.00 g respectively.
The hemoglobin and platelet levels were ?1.05±0.81 g/dL and ?42.79±35.59×103/?L in the test group, and ?1.08±0.97 g/dL and ?27.93±40.49×103/?L, in the control group. The test group showed better outcomes in CBI application time (21.31±12.15 hours) and Foley catheter indwelling time (50.97±14.63 hours) compared to the control group (34.42±22.68 hours and 70.33±33.95 hours) (P＜0.001).
Conclusion: After trans-urethral prostate surgery, thrombin agent instillation can prevent post-operative hematuria and facilitate quicker recovery to daily activities.
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KEYWORD
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Benign prostatic hyperplasia, Hematuria, Thrombin
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